Prediabetes: Progression to Type 2 Diabetes

After 3 years, about 14 out of 100 people who made major lifestyle changes got type 2 diabetes. Compare that to about 22 out of 100 people who took metformin and about 29 out of 100 people who took a placebo pill and got type 2 diabetes. After 10 years, about 27 out of 100 people who made major lifestyle changes got type 2 diabetes. Compare that to about 42 out of 100 people who took metformin and about 52 out of 100 people who took a placebo pill and got type 2 diabetes. After 15 years, about 55 out of 100 people who made major lifestyle changes got type 2 diabetes. Compare that to about 56 out of 100 people who took metformin and about 62 out of 100 people who took a placebo pill and got type 2 diabetes.

Making major lifestyle changes or taking metformin both work better than a placebo pill at delaying or preventing type 2 diabetes. For many people, making major lifestyle changes works better than taking metformin to help delay or prevent type 2 diabetes for up to 10 years. A follow-up study at 15 years showed that making major lifestyle changes was about equal to taking metformin in helping to delay or prevent type 2 diabetes. But doing both of these things may give you the best chance of delaying or preventing type 2 diabetes over the long term.

The information shown here is based on the best available evidence.

Current as of: December 19, 2019

Author: Healthwise Staff
Adam Husney MD - Family Medicine
Kathleen Romito MD - Family Medicine
David C.W. Lau MD, PhD, FRCPC - Endocrinology
Heather Quinn MD - Family Medicine

Prediabetes: Progression to Type 2 Diabetes